Search Site
Home >> Signaling Pathways >> Cancer Biology >> Cancer Biology Peptides >> MAP kinase fragment [Multiple species]
Related Products
MAP kinase fragment [Multiple species]
Lys-Tyr-Ile-His-Ser-Ala-Asn-Val-Leu

MAP kinase fragment [Multiple species]

Catalog No. A1079
Size Price Stock Qty
1mg $50.00 In stock
5mg $150.00 In stock
10mg $250.00 In stock
25mg $350.00 In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

MAP kinase fragment [Multiple species]

MAP kinase fragment [Multiple species] Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

MAP kinase fragment [Multiple species] Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Chemical Properties

Cas No. SDF Download SDF
Synonyms H2N-Lys-Tyr-Ile-His-Ser-Ala-Asn-Val-Leu-OH
Canonical SMILES NC(CCCCN)C(NC(CC1=CC=C(O)C=C1)C(NC(C(CC)C)C(NC(CC2=CN=CN2)C(NC(CO)C(NC(C)C(NC(CC(N)=O)C(NC(C(C)C)C(NC(CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula C48H77N13O13 M.Wt 1044.2
Solubility Storage Store at -20°C
General tips N/A
Shipping Condition N/A

Background

This Mitogen-activated protein kinase (MAP kinase) fragment has a peptide sequence of Lys-Tyr-Ile-His-Ser-Ala-Asn-Val-Leu.

The MAP kinases are serine/threonine-specific protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group.

MAPK pathways are a collection of protein signaling cascades stimulated by a wide variety of extracellular signals, including growth factors, cytokines and environmental stresses. Upon activation, MAPK pathways regulate many fundamental cellular functions, includ­ing differentiation, proliferation and apoptosis, through the activation of specific transcription factors and other regulatory proteins.

MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPK proteins have been repeatedly implicated in the pathogenesis of cancer and autoimmune diseases, leading to their selection as targets for drug development.

A1079_1

Figure 1: x-ray of an ERK2 MAP kinase in its active form.

Ref:

1. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science 298 (5600): 1912–34.

2. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH (April 2001). "Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions". Endocr. Rev. 22 (2): 153–83. 

3. Bandyopadhyay S. et al. “A human MAP kinase interactome”. Nature Methods. 7(2010);801-805.

4. Chang, L. & Karin, M. Mammalian MAP kinase signalling cascades. Nature 410, 37–40 (2001).

5. Widmann, C., Gibson, S., Jarpe, M.B. & Johnson, G.L. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79, 143–180 (1999).

6. Kolch, W., Calder, M. & Gilbert, D. When kinases meet mathematics: the systems biology of MAPK signalling. FEBS Lett. 579, 1891–1895 (2005).

7. Johnson, G.L. & Lapadat, R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911–1912 (2002).