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IL-4, murine recombinant

Catalog No.
P1022
IL-4, pleiotropic cytokine, expressed in E.Coli, species-specific.
Grouped product items
SizePriceStock Qty
10ug
$238.00
Ship with 5-10 days
50ug
$785.00
Ship with 5-10 days
1mg
$4,224.00
Ship with 5-10 days

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Background

IL-4 is a pleiotropic cytokine produced by activated T lymphocytes, basophils, mast cells and bone marrow stromal cells. IL-4 plays an important role in the regulation of isotype switching, differentiation of precursor T helper cells and induction of IgE production in B lymphocytes. Also, IL-4 regulates cell proliferation, survival and gene expression. Excessive IL-4 production by Th2 cells is associated with elevated IgE production and allergy.

The murine IL-4 cDNA encodes a 140 aa protein with a 20 aa signal sequence. Mature mouse IL-4 shares 39%, 39%, and 59% aa sequence identity with bovine, human, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.

Biological Activity

Determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells.
ED50 < 2.0 ng/ml.          
Specific activity > 5*105 units/mg.          

Quality Control

Quality Control & DataSheet

View current batch:
    Purity: ≥98%, by SDS-PAGE and HPLC.
    Endotoxin Level: <0.1 ng/μg
 

Description

Gene ID: 16189 Accession #: P07750
Alternate Names:IL4, BCGF,BCDF, B cell stimulating factor, BSF-1,Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra.
Source: Escherichia Coli. M.Wt: 13.5 kDa
Appearance: Lyophilized protein Storage: Store at -20°C
Formulation:Lyophilized with no additives.
Solubility:Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use.
Shipping Condition: Gel pack. Handling: Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.