Immunology/Inflammation
The adaptive immune system consists of B and T lymphocytes which mediate humoral immunity (e.g. antibody response) and cell-mediated immunity, respectively. B cell receptor and T cell receptor signaling is responsible for activation of Src family tyrosine kinases, such as Blk, Fyn, and Lyn in B cells and Fyn and Lck in T cells, resulting phosphorylation of the receptor-associated ITAM motifs. Phosphorylated ITAMs serve as the docking sites for Syk family tyrosine kinases, e.g. Syk in B cells and Zap-70 in T cells. Activated Syk kinases then propagate the signals via phosphorylation of downstream proteins. Furthermore, lymphocyte receptor signaling facilitates B and T cell development, differentiation, proliferation and survival.
- C3283 2-Trifluoromethyl-2'-methoxychalconeSummary: Nrf2 activator
- C3420 Cannabidiol dimethyl etherSummary: 15-lipoxygenase inhibitor
- C3559 NF-κB Activation Inhibitor IIISummary: NF-κB inhibitor
- C4050 6α-methyl-11β-HydroxyprogesteroneSummary: corticosteroid and anti-inflammatory
- C3973 MusconeSummary: anti-inflammatory effects
- C4123 β-acetyl-Boswellic AcidSummary: non-reducing inhibitor of 5-lipoxygenase (5-LO)
- C4107 N-3-oxo-dodecanoyl-L-Homoserine lactoneSummary: NF-κB and AP-2 activator
- C4126 Bradykinin (acetate)Summary: inflammatory mediator
- C4074 PPM-18Summary: NF-κB inhibitor
- C4161 (S)-LisofyllineSummary: inactive optical enantiomer of (R)-LSF, an anti-inflammatory agent