Flurandrenolide

Flurandrenolide (CAS No.: 1524-88-5) is a synthetic small-molecule corticosteroid classified as a topical glucocorticoid with well-established anti-inflammatory and immunomodulatory properties, widely utilized in dermatological and inflammation-related research. As a steroidal agent, it exerts its biological effects primarily through activation of glucocorticoid receptors, leading to modulation of downstream signaling pathways that suppress pro-inflammatory cytokine production, inhibit immune cell activation, and attenuate tissue inflammatory responses. In addition to its classical glucocorticoid receptor-mediated actions, it has been reported to influence epidermal growth factor receptor signaling, with activity observed in the nanomolar range, suggesting potential cross-talk with proliferative and repair-associated pathways. Flurandrenolide is commonly employed in cellular and tissue-based models to study mechanisms of skin inflammation, allergic responses, and corticosteroid signaling, as well as in preclinical models investigating inflammatory skin disorders and therapeutic response. Its pharmacological profile makes it a useful reference compound in drug discovery programs focused on anti-inflammatory agents and steroid receptor biology, with experimental concentrations or dosing regimens typically adjusted according to specific assay conditions and research objectives.