|Mcl1-IN-1 Myeloid cell factor 1 inhibitor|
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||713492-66-1||SDF||Download SDF|
|Chemical Name||2-(2-((5-chloro-8-hydroxyquinolin-7-yl)(pyridin-2-ylamino)methyl)phenoxy)acetic acid|
|Solubility||Soluble in DMSO||Storage||Store at -20°C|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
Mcl1-IN-1 is a small molecule, potent and selective inhibitor of myeloid cell factor 1 (Mcl-1) with an IC50 value of 2.4 μM .
Mcl1-IN-1 has been reported to potently inhibit Mcl-1 which acted as an important therapeutic target for the treatment of non-solid tumor and solid tumor malignancies with an IC50 value of 2.4 μM. The inhibition ability of Mcl1-IN-1 to Mcl-1 was 40-fold more than Bcl-xL of which IC50 is 100 μM. Mcl1-IN-1 has the favorable physicochemical properties, for example, lack of any apparent toxicophores .
 Richard DJ1, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH.Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1; 21(21):6642-9.