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IGF-II, human recombinant

Catalog No.
P1017
IGF-II, endocrine hormone, expressed in E.Coli, cross-species activity.
Grouped product items
SizePriceStock Qty
10ug
$106.00
Ship with 5-10 days
50ug
$251.00
Ship with 5-10 days
1mg
$1,848.00
Ship with 5-10 days

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Background

Insulin-like Growth Factor-II (IGF-II) is a polypeptide endocrine hormone structurally similar to insulin and belongs to insulin-like growth factor family. IGF-II have a much higher growth-promoting activity than insulin and binds to the tyrosine kinase type I receptor (IGF-IR) and the IGF-II/Mannose-6-phosphate receptor. IGF-II expression is influenced by placenta lactogen.

Human IGF-II is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides, which are proteolyzed to produce the identical 7.5 kDa mature IGF-II. Mature IGF-II is highly conserved between the human, bovine and porcine proteins (100% identity), and exhibits cross-species activity. Recombinant Human IGF-II is a 7.5 kDa protein containing 67 amino acid residues.

Biological Activity

Determined by competitive binding against plasma-derived IGF-II to human placental membranes.
ED50 < 1.0 ng/ml.          
Specific activity > 1*106 units/mg.          

Quality Control

Quality Control & DataSheet

View current batch:
    Purity: ≥98%, by SDS-PAGE and HPLC.
    Endotoxin Level:< 0.1 ng/μg

Related Biological Data

IGF-II

Related Biological Data

IGF-II
 

Description

Gene ID: 3481 Accession #: P01344
Alternate Names:Human IGF-II, IGF-II, IGFII, IGFII, IGF2, IGF-2, IGF 2, h-IGF-II, rh-IGF-II, recombinant human IGF-II, recombinant IGF-II, IGF.
Source: Escherichia Coli. M.Wt: 7.5 kDa
Appearance: Lyophilized protein Storage: Store at -20°C
Formulation:Lyophilized with no additives.
Solubility:Reconstitute in 10 mM acetic acid to a concentration of 0.1-1 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use.
Shipping Condition: Gel pack. Handling: Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.