Signaling pathways
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BA5497 VU6028418Summary: VU6028418 is a potent, highly selective antagonist with oral activity. - BA5498 ML380Summary: ML380 is a potent, subtype-selective and blood-brain-barrier-crossing orthosteric modulator (PAM) with values of 190 and 610 nM for human and rat M5, respectively.
- BA5499 PentoxyverineSummary: Pentoxyverine (Carbetapentane) is an orally active receptor agonist with σ1 values of 41nM, 894nM and 75nM in for σ1, σ2 and guinea pig brain membranes, respectively.
- BA5501 SolifenacinSummary: Solifenacin is a novel muscarinic receptor antagonist.
- BA5502 ImidafenacinSummary: Imidafenacin (KRP-197; ONO-8025) is a potent and selective M3 receptor inhibitor.
- BA5503 DarifenacinSummary: Darifenacin (UK88525) is an M3 muscarinic-type receptor antagonist.
- BA5504 PQCASummary: PQCA is a highly selective and potent modulator of muscarinic receptor-positive mutations.
- BA5505 JHU37160Summary: JHU37160 is a potent and permeable agonist across the blood-brain barrier.
- BA5506 AceclidineSummary: Aceclidine (Quinuclidin-3-ylacetate) is a modulator and agonist of the M3 muscarinic acetylcholine receptor (EC:40 μM).
- BA5507 VU0467485Summary: VU0467485 (AZ13713945) is a potent, selective, orally bioavailable muscarinic acetylcholine receptor 4 orthosteric modulator (PAM).