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Bioactive Compounds
Signaling Pathways

Signaling Pathways

A8320 PF-00562271

Target: FAK|Pyk2

Summary: FAK/Pyk2 inhibitor,potent and ATP-competitive

insoluble in EtOH; insoluble in H2O; ≥11.1 mg/mL
A8321 Cisplatin
34 Citation

Summary: chemotherapeutic compound
A8322 Neratinib (HKI-272)
3 Citation

Target: EGFR

Summary: HER2/EGFR inhibitor,potent and irreversible

insoluble in H2O; ≥13.93 mg/mL
A8323 WP1130
1 Citation

Summary: Deubiquitinase (DUB) inhibitor, Cell permeable

≥38.4 mg/mL
A8324 LDN-193189
8 Citation

Target: BMP and Other Activin Receptors

Summary: ALK inhibitor,potent and selective

insoluble in DMSO; insoluble in EtOH; insoluble in H2O
A8325 Tivantinib (ARQ 197)
2 Citation

Target: MET

Summary: C-Met inhibitor,non-ATP-competitive

≥18.47 mg/mL
A8326 AZD-5438
2 Citation

Target: Cyclin-Dependent Kinases

Summary: Potent CDK1/2/9 inhibitor

insoluble in H2O; ≥18.55 mg/mL
A8328 LDK378

Target: ALK

Summary: Potent ALK inhibitor

insoluble in H2O; ≥13.95 mg/mL
A8332 R788 disodium

Target: Syk

Summary: Syk inhibitor,ATP competitive and potent

≥62.4 mg/mL
A8333 Canagliflozin
1 Citation

Target: SGLT

Summary: SGLT2 inhibitor,potent and selective

≥22.25 mg/mL