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Bioactive Compounds
Signaling Pathways

Signaling Pathways

A4213 Necrostatin-1
32 Citation

Target: RIP kinases

Summary: RIP1 inhibitor

insoluble in H2O; ≥12.97 mg/mL
A4216 Thalidomide

Target: Ubiquitin E3 Ligases

Summary: Immunomodulatory agent,sedative drug,angiogenesis inhibitor

insoluble in H2O; insoluble in EtOH; ≥11.8 mg/mL
A4217 QNZ (EVP4593)
4 Citation

Summary: Potent NF-κB inhibitor
A4219 Birinapant (TL32711)
9 Citation

Summary: Potent XIAP/cIAP1 antagonist

≥40.35 mg/mL
A4221 YM155
2 Citation

Target: Survivin

Summary: Survivin suppressant,apoptosis inhibitor

≥22.15 mg/mL
A4224 GDC-0152
2 Citation

Target: Inhibitor of apoptosis proteins (IAP)

Summary: IAP antagonist,potent amd samll-molecule

≥24.95 mg/mL
A4227 Tipifarnib (Zarnestra)

Summary: Farnesyltransferase inhibitor,potent and specific

insoluble in H2O; ≥8.16 mg/mL
A4228 Nutlin-3

Target: MDM2

Summary: MDM2 antagonist,inhibits MDM2-p53 interaction

≥58.2 mg/mL
A4230 NSC 66811

Summary: MDM2 inhibitor

≥34 mg/mL
A4232 Cyclophosphamide monohydrate

Summary: alkylating, cytotoxic agent,antitumor activity

≥13.95 mg/mL