AMG 510
Catalog No.
B8399
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AMG 510 (CAS 2296729-00-3) is an orally bioavailable, selective covalent inhibitor targeting KRAS G12C. Its mechanism involves binding KRAS G12C mutant protein and stabilizing it in an inactive GDP-bound conformation. By preventing nucleotide exchange, AMG 510 suppresses downstream signaling pathways linked to cellular proliferation and survival, resulting in tumor regression in preclinical KRAS G12C-driven cancer models. It serves as an important tool for biomedical research focused on RAS-driven oncogenic signaling and targeted cancer therapeutics development.
| Storage | Store at -20°C |
| M.Wt | 560.59 |
| Cas No. | 2296729-00-3 |
| Formula | C30H30F2N6O3 |
| Solubility | insoluble in H2O; ≥27.4 mg/mL in EtOH; ≥42.3 mg/mL in DMSO |
| Chemical Name | 4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one |
| SDF | Download SDF |
| Canonical SMILES | O=C(N1CCN([C@@H](C)C1)C2=NC(N(C3=C2C=C(C(C4=C(O)C=CC=C4F)=N3)F)C5=C(C=CN=C5C(C)C)C)=O)C=C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
