RMC-7977
Catalog No.
BA5764
RMC-7977 is a reversible triple complex inhibitor with broad-spectrum activity against both mutant and wild-type (WT) KRAS, NRAS and HRAS variants.
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RMC-7977 is a reversible triple-complex inhibitor with broad-spectrum activity against both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants.RMC-7977 leads to tumor regression and is well-tolerated in a variety of RAS-addicted preclinical cancer models.RMC-7977 also inhibits growth in KRAS cancer models.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 865.09 |
| Cas No. | 2765082-12-8 |
| Formula | C47H60N8O6S |
| Solubility | ≥24.85 mg/mL in DMSO; ≥43.5 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | (3R,4r,5S)-N-((63S,4S,Z)-12-(5-(4-cyclopropylpiperazin-1-yl)-2-((S)-1-methoxyethyl)pyridin-3-yl)-11-ethyl-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)tetrahydro-2H-pyr |
| SDF | Download SDF |
| Canonical SMILES | C[C@H](OC)C(N=CC(N1CCN(C2CC2)CC1)=C3)=[C@@]3[C@](N4CC)=C(CC(C)(C)COC([C@H]5NN(C([C@@H](NC([C@H]6[C@H]7[C@@H]6COC7)=O)CC8=NC9=CS8)=O)CCC5)=O)C%10=C4C=CC9=C%10 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
