MRTX-1133
Catalog No.
B8761
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MRTX-1133 (CAS: 2621928-55-8) is a non-covalent alkyne-based inhibitor specifically targeting the KRAS G12D mutant protein. It binds KRAS G12D with sub-picomolar affinity, occupying the Switch II pocket and forming multiple intermolecular interactions. Through these interactions, MRTX-1133 disrupts SOS1-mediated guanine nucleotide exchange and prevents the assembly of KRAS-GTP/RAF1 signaling complexes, thereby inhibiting downstream KRAS-driven signaling pathways. MRTX-1133 is applied in cancer biology research to investigate tumor signaling and therapeutic strategies involving KRAS G12D mutations.
| Storage | Store at -20°C |
| M.Wt | 600.65 |
| Cas No. | 2621928-55-8 |
| Formula | C33H31F3N6O2 |
| Solubility | ≥46.2 mg/mL in DMSO; ≥21.05 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol |
| SDF | Download SDF |
| Canonical SMILES | C#CC1=C(F)C=CC2=CC(O)=CC(C3=C(F)C4=NC(OC[C@]56C[C@@H](F)CN5CCC6)=NC(N7C[C@H]8N[C@H](CC8)C7)=C4C=N3)=C12 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
