N3-kethoxal
Catalog No.
A8793
membrane-permeable nucleic acid probe
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N3-kethoxal (CAS 2382756-48-9) is a synthetic, membrane-permeable nucleic acid probe containing an azide functional group. This compound reacts preferentially with unpaired guanine bases in RNA and single-stranded DNA regions, forming stable covalent adducts and introducing an azide moiety for subsequent bioorthogonal click chemistry. Through this mechanism, N3-kethoxal facilitates labeling and structural probing of RNA secondary and tertiary conformations, genomic mapping of accessible DNA regions, characterization of RNA-RNA interaction dynamics, and identification of RNA-protein proximity interactions, applicable in both in vitro assays and in vivo cellular contexts.
- 1. Georgi K. Marinov, William J. Greenleaf, et al. "Mapping the Simultaneously Accessible and ssDNA-Containing Genome With KAS-ATAC Sequencing." Bio Protoc. 2025 May 5;15(9):e5306 PMID: 40364983
- 2. Yinan Wang, Feng Tang, et al. "N 2-Alkyl-dG lesions elicit R-loop accumulation in the genome." Nucleic Acids Res. 2024 Oct 1:gkae845. PMID: 39351875
- 3. Georgi K Marinov, Samuel H Kim, et al. "CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping." Genome Biol. 2023 Apr 21;24(1):85. PMID: 37085898
| Storage | Store at -20°C |
| M.Wt | 189.17 |
| Formula | C6H11N3O4 |
| Solubility | Soluble in DMSO |
| Chemical Name | 3-(2-azidoethoxy)-1,1-dihydroxybutan-2-one |
| SDF | Download SDF |
| Canonical SMILES | CC(OCCN=[N+]=[N-])C(C(O)O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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