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Bioactive Compounds

Bioactive Compounds

A4164 AZD2461

Target: PARP

Summary: Novel PARP inhibitor

insoluble in H2O; ≥16.35 mg/mL
A4032 VX-222 (VCH-222, Lomibuvir)

Target: HCV polymerase

Summary: NNI of HCV RNA polymerase

≥44.6 mg/mL
A4096 Belinostat (PXD101)
2 Citation

Target: Histone Deacetylases (HDACs)

Summary: Hydroxamate-type HDAC inhibitor

insoluble in H2O; ≥15.92 mg/mL
A8201 Amprenavir (agenerase)

Summary: HIV-1 protease inhibitor
A4120 MK-5108 (VX-689)

Summary: Aurora-A kinase inhibitor,highly selective

≥23.1 mg/mL
A4010 Salinosporamide A (NPI-0052, Marizomib)

Target: Proteasome

Summary: 20S proteasome inhibitor

Soluble in DMSO
A4309 GW501516
1 Citation

Summary: PPARδ agonist,selective and potent

insoluble in H2O; ≥18.05 mg/mL
A4331 GSK256066

Summary: PDE4-inhibitor, selective and highly potent

insoluble in DMSO; insoluble in EtOH; insoluble in H2O
A4385 Ganetespib (STA-9090)
3 Citation

Summary: Hsp90 inhibitor,non-geldanamycin

insoluble in H2O; ≥18.22 mg/mL
A3191 Ascomycin(FK 520)

Target: phosphatases

Summary: Macrolide immunosuppressant,FK-520 analog

≥38.9 mg/mL