|signal transducer and activator of transcription 6 fragment
STAT6 transcription factor
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||SDF||Download SDF|
|Solubility||Storage||Store at -20°C|
Signal transducer and activator of transcription 6 fragment, (C54H81N13O15), a peptide with the sequence H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH, MW= 1152.3. STAT6 is a member of the STAT family of transcription factors(1). In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators(2). This protein plays a central role in exerting IL4 mediated biological responses(3). It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.
Figure1 structure of STAT6
Figure2 signal pathway of STAT6
1. Leek JP, Hamlin PJ, BellSM, LenchNJ(1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 208–9.
2. Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene 285 (1–2): 1–24.
3. Shimoda K, van Deursen J, Sangster MY, et al. (1996). "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene". Nature 380 (6575): 630–3.