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Q-VD(OMe)-OPh

Catalog No.
A8165
Pan-caspase inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$570.00
In stock
Evaluation Sample
$28.00
In stock
1mg
$110.00
In stock
5mg
$300.00
In stock
10mg
$500.00
In stock
25mg
$800.00
In stock

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Email: [email protected]

Worldwide Distributors

Background

Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad spectrum caspase inhibitor,  provides a cost effective, non toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors. [1] It is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk. Q-VD-OPh is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase 12. In addition to the increased effectiveness, Q-VD-OPh was not toxic to cells, even at high concentrations. Q-VD-OPh is equally effective at inhibiting the three major apoptotic pathways, it can inhibit recombinant caspases 1, 3, 8, and 9 with IC50 values ranging from 25 to 400 nM2. The effectiveness of Q-VD-OPh as an apoptotic inhibitor is evidenced by the complete suppression of an apoptotic inducer capable of inducing substantial cell death in less than 4 hours. [2] Q-VD-OPh protected against the substantial apoptosis induced by actinomycin D. In addition, Q-VD-OPh alone exhibited little or no toxicity, even at extremely high concentrations.

Ref:

  1. 1.  T. M. Caserta, A. N. Smith, A. D. Gultice, M. A. Reedy and T. L. Brown, Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties, Apoptosis 2003; 8: 345–352
  2. Yin XM. Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res 2000; 10: 161–167

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt527
FormulaC26H25F2N3O6
SynonymsQ-VD(OMe)-OPh
Solubility≥26.35mg/mL in DMSO, ≥97.4 mg/mL in EtOH,insoluble in H2O
Chemical Name(S)-methyl 5-(2,6-difluorophenoxy)-3-((S)-3-methyl-2-(quinoline-2-carboxamido)butanamido)-4-oxopentanoate
SDFDownload SDF
Canonical SMILESO=C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](CC(OC)=O)C(COC1=C(F)C=CC=C1F)=O)=O)C2=NC3=CC=CC=C3C=C2
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Q-VD(OMe)-OPh

Related Biological Data

Q-VD(OMe)-OPh

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Q-VD(OMe)-OPh

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Q-VD(OMe)-OPh

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Q-VD(OMe)-OPh

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Q-VD(OMe)-OPh

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Q-VD(OMe)-OPh

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Q-VD(OMe)-OPh