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Catalog No.
Clk4 inhibitor,highly selective
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SizePriceStock Qty
10mM (in 1mL DMSO)
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In stock
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ML167 is a highly selective inhibitor of Cdc2-like kinase 4 (Clk4) with IC50 value of 136nM [1].

The Clk family enzymes play their roles in gene splicing via phosphorylating the major component of the spliceosome, SR proteins. Small molecule probes that target Clk’s can be used to study the modulating functions of these kinases in gene splicing. ML167 is found as the first fully selective inhibitor of Clk4 but not other related kinases including Clk1, Clk2 and Clk3 and Dyrk1A/1B. It is 10-fold more potent against Clk4 over other kinases. The treatment of ML167 on Caco-2 cells proves that ML167 is highly cell-permeable. Besides that, ML167 is also found to be an ATP-competitive inhibitor [1].

[1] Rosenthal A S, Tanega C, Shen M, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2011.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.1285702-20-6
Solubility≥16.75mg/mL in DMSO
SDFDownload SDF
Canonical SMILESCC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description ML167 is a highly selective inhibitor of Cdc2-like kinase 4 (Clk4) with IC50 value of 136 nM.
Targets Clk4          
IC50 136 nM          

Quality Control

Chemical structure