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IOX 1

Catalog No.
B5607
histone demethylase JMJD inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$80.00
In stock
10mg
$89.00
In stock
50mg
$355.00
In stock

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Email: [email protected]

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Background

IOX 1 (5-carboxy-8HQ) is an inhibitor of histone demethylase JMJD with IC50 values of 0.2 μM for JMJD2E [1].

The Jumonji domain (JMJD) is a histone demethylase and acts as a transcriptional repressor.

IOX 1 is a histone demethylase JMJD inhibitor. In the FDH-coupled assay, IOX 1 inhibited JMJD2E with IC50 value of 0.2 μM. In MALDI-TOF MS assay, IOX 1 inhibited JMJD2E, JMJD2A, FIH and PHD2 with IC50 values of 2.4, 1.7, 20.5 and 14.3 μM, respectively. In HeLa cells, IOX 1 increased H3K9me3 fluorescence intensity, suggesting that IOX 1 inhibited H3K9me3 demethylation induced by JMJD2A with IC50 value of 86.5 μM. Also, IOX 1 exhibited cytotoxicity with IC50 value of 291.6 μM [1].

Reference:
[1].  King ON, Li XS, Sakurai M, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One, 2010, 5(11): e15535.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt189.17
Cas No.5852-78-8
FormulaC10H7NO3
Solubility≥5.75mg/mL in DMSO
Chemical Name8-hydroxyquinoline-5-carboxylic acid
SDFDownload SDF
Canonical SMILESOC1=C2N=CC=CC2=C(C(O)=O)C=C1
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases.
Targets 2OG oxygenases          
IC50            

Quality Control

Quality Control & MSDS

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Chemical structure

IOX 1

Related Biological Data

IOX 1