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Dapivirine (TMC120)

In stock
Catalog No.
A8554
Nonnucleoside reverse transcriptase inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$110.00
In stock
5mg
$103.00
In stock
25mg
$329.00
In stock

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Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor with a favorable safety profile following vaginal application.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt329.4
Cas No.244767-67-7
FormulaC20H19N5
SynonymsTMC 120;TMC-120
Solubility≥13.5mg/mL in DMSO
Chemical Name4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile
SDFDownload SDF
Canonical SMILESCC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description Dapivirine (TMC120) is a non-nucleoside inhibitor of HIV reverse transcriptase with an IC50 vaule of 24 nM.
Targets HIV reverse transcriptase          
IC50 24 nM          

Quality Control

Quality Control & MSDS

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Chemical structure

Dapivirine (TMC120)