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Cyclo (-RGDfK)

In stock
Catalog No.
A8164
Inhibitor of αvβ3 integrin
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$150.00
In stock
Evaluation Sample
$28.00
In stock
5mg
$105.00
In stock
25mg
$335.00
In stock
100mg
$699.00
In stock

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Background

In one study where this peptide was labeled with 125I, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. The integrin alpha(IIb)beta(3)-specific cyclic hexapeptide contains an Arg-Gly-Asp (RGD) sequence.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt603.7
Cas No.161552-03-0
FormulaC27H41N9O7
SynonymsCyclo(-Arg-Gly-Asp-D-Phe-Lys)
Solubility≥30.185mg/mL in DMSO, <2.59 mg/mL in EtOH, ≥59.2 mg/mL in H2O
Chemical Name2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
SDFDownload SDF
Canonical SMILESC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.
Targets Integrin          
IC50            

Quality Control

Chemical structure

Cyclo (-RGDfK)

Related Biological Data

Cyclo (-RGDfK)

Related Biological Data

Cyclo (-RGDfK)

Related Biological Data

Cyclo (-RGDfK)