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Cyclo (-RGDfK) Inhibitor of αvβ3 integrin

Catalog No.A8164
Size Price Stock Qty
10mM (in 1mL DMSO)
$150.00
In stock
Evaluation Sample
$28.00
In stock
5mg
$105.00
In stock
25mg
$335.00
In stock
100mg
$699.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Cyclo (-RGDfK)

Related Biological Data

Cyclo (-RGDfK)

Biological Activity

Description Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.
Targets Integrin          
IC50            

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Chemical Properties

Cas No. 161552-03-0 SDF Download SDF
Synonyms Cyclo(-Arg-Gly-Asp-D-Phe-Lys)
Chemical Name 2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
Canonical SMILES C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O
Formula C27H41N9O7 M.Wt 603.7
Solubility >30.2mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

In one study where this peptide was labeled with 125I, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. The integrin alpha(IIb)beta(3)-specific cyclic hexapeptide contains an Arg-Gly-Asp (RGD) sequence.