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C34

Catalog No.
B4925
TLR4 inhibitor
Grouped product items
SizePriceStock Qty
5mg
$86.00
In stock
10mg
$132.00
In stock
25mg
$263.00
In stock
50mg
$421.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

C34 is a 2-acetamidopyranoside that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM. It does not affect signaling through either TLR2 or TLR9[1,2]. 

C34, used at 1 mg/kg can reduce systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1]. 

C34 markedly decreases the basal expression of TNFα, as well as LPS-induced iNOS and TNFα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis[1]. 

References:

[1]. Neal M D, Jia H, Eyer B, et al. Discovery and validation of a new class of small molecule toll-like receptor 4 (TLR4) inhibitors. PLoS One, 2013, 8(6): e65779.

[2]. Wipf P, Eyer B R, Yamaguchi Y, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Letters, 2015, 56(23): 3097-3100.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt389.4
Cas No.40592-88-9
FormulaC17H27NO9
SolubilitySoluble in DMSO
Chemical Name(2R,3S,4R,5R,6S)-5-acetamido-2-(acetoxymethyl)-6-isopropoxytetrahydro-2H-pyran-3,4-diyl diacetate
SDFDownload SDF
Canonical SMILESCC(C)O[[email protected]]1O[[email protected]](COC(C)=O)[[email protected]@H](OC(C)=O)[[email protected]](OC(C)=O)[[email protected]]1NC(C)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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