CU CPT 4a
Catalog No.
B5752
TLR3 inhibitor
Featured Products
CU CPT 4a is a selective TLR3 inhibitor with IC50 of 3.44 μM in RAW 264.7 cells. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells. It reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.
References:
[1]. Cheng K, Wang X, Yin H. Small-Molecule Inhibitors of the TLR3/dsRNA Complex. Journal of the American Chemical Society, 2011, 133(11): 3764-3767.
[2]. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nature Communications, 2014, 5.
- 1. Apiwit Sae-Fung, Thanpisit Lomphithak, et al. "IFN-γ enhances Poly (I: C)-induced necroptosis and immunogenic cell death via TLR3 upregulation in cholangiocarcinoma cells." European Journal of Pharmaceutical Sciences Available online 15 September 2025, 107274
- 2. Cong Li, Jinxian Huang, et al. "Pyridoxal-5'-Phosphate Promotes Immunomodulatory Function of Adipose-Derived Mesenchymal Stem Cells through Indoleamine 2,3-Dioxygenase-1 and TLR4/NF-κB Pathway." Stem Cells International. Volume 2019, Article ID 3121246, 15 pages
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 377.82 |
| Cas No. | 1279713-77-7 |
| Formula | C18H13ClFNO3S |
| Solubility | <37.78mg/ml in DMSO |
| Chemical Name | (R,Z)-2-(((3-chloro-6-fluorobenzo[b]thiophen-2-yl)(hydroxy)methylene)amino)-3-phenylpropanoic acid |
| SDF | Download SDF |
| Canonical SMILES | OC([C@@H](Cc1ccccc1)/N=C(/c([s]c1c2ccc(F)c1)c2Cl)\O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
