Biochemical Reagent
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BA3684 XL01126Summary: XL01126 is a potent (14 nM (G2019SLRRK2) and 32 nM (WTLRRK2)) consisting of the VHL ligand VH101,thiol (HY-47851, blue portion) and inhibitor HG-10-102-01 (HY-13488, red portion). -
BA3685 PFE-360Summary: PFE-360 (PF-06685360) is a potent, selective, blood-brain barrier-crossing, orally effective inhibitor. - BA3686 JH-II-127Summary: JH-II-127 an orally effective, highly potent, selective and brain-permeable inhibitor with values of 6, 2 and 48 nM for wild-type and and mutant, respectively.
- BA3687 GSK2646264Summary: GSK2646264 is a potent and selective inhibitor of spleen tyrosine kinase.
- BA3688 PF-06454589Summary: PF-06447475 is a potent, selective, blood-brain barrier permeable kinase inhibitor targeting WTLRRK and G2019S with values of 3nM and 11nM, respectively.
- BA3689 EB-42486Summary: A novel effective and highly selective inhibitor.
- BA3691 LRRK2-IN-7Summary: LRRK2-IN-7 is a potent, selective, CNS-permeable kinase inhibitor.
- BA3692 BC1618Summary: BC1618, an inhibitor with oral activity, stimulates signaling (prevents activated pAmpkα from being degraded by the Fbxo48-mediated proteasome).
- BA3693 AUTAC4Summary: AUTAC4 is an autophagy-targeting chimera that targets mitochondria.
- BA3694 GSK3-IN-3Summary: GSK3-IN-3 is a mitochondrial autophagy inducer that induces parkin-dependent mitochondrial autophagy.