Biochemical Reagent
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BA8440 AtabecestatSummary: Atabecestat (JNJ-54861911) is a potent brain-permeable and orally active beta-site amyloid precursor protein cleaving enzyme 1 inhibitor that potently reduces reduced Aβ protein expression in cerebrospinal fluid. - BA8441 BACE2-IN-1Summary: BACE2-IN-1 is a highly selective inhibitor with an inhibition constant of 1.6 nM.
- BA8442 ElenbecestatSummary: Elenbecestat (E2609) is a highly potent, orally active, CNS permeable inhibitor.
- BA8443 UmibecestatSummary: Umibecestat (CNP520) is a β-site amyloid precursor protein cleavage enzyme-1 inhibitor with values of 11 nM and 10 nM in human BACE-1 and murine BACE-1, respectively.
- BA8444 BACE1-IN-1Summary: A potent and highly brain permeable inhibitor.
- BA8445 CassiasideSummary: Cassiaside is a naphthyl ketone glycoside that exhibits a mixed type of inhibition (.
- BA8446 PF-06751979Summary: PF-06751979 is an effective.
- BA8447 AloeninSummary: Aloenin (AloeninA) is a natural product with potent scavenging activity against peroxyl radicals and moderate inhibitory activity against β-secretase (IC50=14.95 μg/mL).
- BA8448 CS587Summary: CS587 is a specific inhibitor and is neurocytotoxic at 10 μM.
- BA8449 TIM-063Summary: TIM-063 is a selective and cell permeable inhibitor.