DNA Damage/DNA Repair
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
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BA3975 DHX9-IN-1Summary: DHX9-IN-1 (example160) is an inhibitor of the ATP-dependent RNA de-helicase A (DHX9). - BA3982 116-9eSummary: 116-9e (MAL2-11B) is a co-chaperone inhibitor.
- BA3984 PyrazofurinSummary: Pyrazofurin is a pyrimidine nucleoside analog with antitumor activity that inhibits cell proliferation and intracellular DNA synthesis through inhibition.
- BA3986 ERCC1-XPF-IN-2Summary: ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF nucleic acid endonuclease.
- BA3988 EthynylcytidineSummary: Ethynylcytidine (ECyD) is a nucleoside analog that is a potent inhibitor of RNA synthesis, inhibiting RNA polymerases I, II and II.
- BA3992 NVS-SM2Summary: NVS-SM2 is a potent, orally active and splicing enhancer that crosses the blood-brain barrier.
- BA3994 BMVCSummary: BMVC is a potent G-quadruplex stabilizer and selective telomerase inhibitor.
- BA3995 3-DeazauridineSummary: 3-Deazauridine (NSC126849) is a uridine analog.
- BA3997 DHODH-IN-16Summary: DHODH-IN-16 is a potent dihydroorotic acid dehydrogenase inhibitor.
- BA4005 Brr2-IN-3Summary: Brr2-IN-3 is a potent and selective deconjugate inhibitor.