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Tyrphostin 9

Catalog No.
B1494
Selective EGFR/PDGFR inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
25mg
$50.00
In stock
50mg
$60.00
In stock

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Email: [email protected]

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Background

Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5μM [1].

Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991. It also has inhibitory effect on the proliferation of SMC. Tyrphostin 9 potently inhibits the PDGF-dependent SMC proliferation with IC50 value of 40nM and inhibits the PDGF-dependent autophosphorylation of PDGFR with IC50 value of ~2.5μM. Besides that, Tyrphostin 9 also affects the phosphorylation of PLCγ (IC50 value of about 2.5μM) and the PDGF-dependent c-fos expression. Moreover, Tyrphostin 9 is found to be an inhibitor of EGFR with IC50 value of 460μM [1, 2].

In the rat carotid artery injury model, treatment of Tyrphostin 9 significantly reduces neointimal hyperplasia through inhibiting the tyrosine phosphorylation in injured arteries [1].

References:
[1] Levitzki A. PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovascular research, 2005, 65(3): 581-586.
[2] Levitzki A. Tyrphostins—potential antiproliferative agents and novel molecular tools. Biochemical pharmacology, 1990, 40(5): 913-918.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt282.38
Cas No.10537-47-0
FormulaC18H22N2O
Solubility≥14.1mg/mL in DMSO
Chemical Name2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
SDFDownload SDF
Canonical SMILESCC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description Tyrphostin 9 is an inhibitor of EGFR and PDGFR with IC50 values of 460 μM and 0.5 μM, respectively.
Targets PDGFR EGFR        
IC50 0.5 μM 460 μM        

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