In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5μM .
Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991. It also has inhibitory effect on the proliferation of SMC. Tyrphostin 9 potently inhibits the PDGF-dependent SMC proliferation with IC50 value of 40nM and inhibits the PDGF-dependent autophosphorylation of PDGFR with IC50 value of ~2.5μM. Besides that, Tyrphostin 9 also affects the phosphorylation of PLCγ (IC50 value of about 2.5μM) and the PDGF-dependent c-fos expression. Moreover, Tyrphostin 9 is found to be an inhibitor of EGFR with IC50 value of 460μM [1, 2].
In the rat carotid artery injury model, treatment of Tyrphostin 9 significantly reduces neointimal hyperplasia through inhibiting the tyrosine phosphorylation in injured arteries .
 Levitzki A. PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovascular research, 2005, 65(3): 581-586.
 Levitzki A. Tyrphostins—potential antiproliferative agents and novel molecular tools. Biochemical pharmacology, 1990, 40(5): 913-918.
|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Solubility||≥14.1mg/mL in DMSO|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Description||Tyrphostin 9 is an inhibitor of EGFR and PDGFR with IC50 values of 460 μM and 0.5 μM， respectively.|
|IC50||0.5 μM||460 μM|
Quality Control & MSDS
- View current batch:
Purity = 99.88%
- COA (Certificate Of Analysis)
- HPLC (Retest)
- NMR (Nuclear Magnetic Resonance)
- MSDS (Material Safety Data Sheet)