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Ro 31-8220

pan-PKC inhibitor

Ro 31-8220

Catalog No. B1287
Size Price Stock Qty
10mg $143.00 In stock
50mg $428.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

Ro 31-8220

Biological Activity

Description Ro 31-8220 is a inhibitor of pan-PKC with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively,
Targets PKC-α PKC-βII PKC-βI PKC-ε PKC-γ  
IC50 5 nM 14 nM 24 nM 24 nM 27 nM  

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Chemical Properties

Cas No. 125314-64-9 SDF Download SDF
Chemical Name 3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl carbamimidothioate
Canonical SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N
Formula C25H23N5O2S M.Wt 457.55
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Ro 31-8220, a staurosporine analog, is a cell-permeable inhibitor of PKC (protein kinase C) isoforms PKC α, PKC βI, PKC βII, PKC γ, and PKC ε (IC50 = 5, 24, 14, 27, and 24 nM, respectively).