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Marinopyrrole A

In stock
Catalog No.
B1080
Selective Mcl-1 inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$160.00
In stock
5mg
$143.00
In stock
10mg
$234.00
In stock
50mg
$858.00
In stock
100mg
$1,196.00
In stock

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Background

Marinopyrrole A is a selective inhibitor of Mcl-1 with IC50 value of 10.1μM [1].

Marinopyrrole A is a natural product froma species of marine-derived streptomycetes and is reported to be an antagonist of Mcl-1. Mcl-1 is a member of the anti-apoptotic Bcl-2 family, which is a well-validated drug target for cancer treatment. NMR titration experiments show that Marinopyrrole A can directly interact with Mcl-1. It can prevent Bim-BH3 peptides from binding to Mcl-1 but not Bcl-XL. The cell based assay shows a high selectivity of Marinopyrrole A. Treatment with Marinopyrrole A inhibit the viability of K562 cells transfected with Mcl-1 gene with EC50 value of 1.6μM. The selectivity is more than 40-fold greater over the cells transfected with Bcl-XL gene. Moreover, Marinopyrrole A can decreases Mcl-1 expression by increasing the cleavage of caspase-3 and PARP. Marinopyrrole A is also reported to completely restore the sensitivity of multidrug resistant leukemia cells to ABT-737 [1].

References:
[1] Doi K, Li R, Sung SS, et al. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem. 2012 Mar, 287(13): 10224-35.

Chemical Properties

StorageStore at -20°C
M.Wt510.15
Cas No.1227962-62-0
FormulaC22H12Cl4N2O4
SolubilitySoluble in DMSO
SDFDownload SDF
Canonical SMILESOC1=CC=CC=C1C(C2=C(N3C(C(C4=CC=CC=C4O)=O)=CC(Cl)=C3Cl)C(Cl)=C(Cl)N2)=O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description Marinopyrrole A is a selective inhibitor of Mcl-1 with IC50 value of 10.1 μM .
Targets Mcl-1          
IC50 10.1 μM          

Quality Control

Quality Control & MSDS

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Chemical structure

Marinopyrrole A