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I-BET 151 hydrochloride

Catalog No.
BET bromodomain inhibitor
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I-BET 151 dihydrochloride is a bET bromodomain inhibitor that prevents BET from recruiting to chromatin. I-BET 151 induces MLL-fusion leukemia cell line apoptosis and G0 / G1 cell cycle arrest in vitro, and reduces BCL2 expression in NOMO1 cells. I-BET 151 improves the survival rate of two kinds of MLL fusion leukemia mice, and enhances the differentiation of human iPSCs into megakaryocytes. 


[1]. Malherbe P, Masciadri R, Norcross R D, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. British journal of pharmacology, 2008, 154(4): 797.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.1883545-47-8
SolubilitySoluble in DMSO
Chemical Name7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2-ol hydrochloride
SDFDownload SDF
Canonical SMILESCC1=NOC(C)=C1C2=CC3=NC=C(N=C(O)N4[[email protected]](C5=CC=CC=N5)([H])C)C4=C3C=C2OC.Cl
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

I-BET 151 hydrochloride

Related Biological Data

I-BET 151 hydrochloride