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| Fludarabine Phosphate (Fludara)
Inhibits STAT1 activation and DNA synthesis |
Sample solution is provided at 25 µL, 10mM.
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Quality Control & MSDS
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Chemical structure
| Description | Fludarabine is an inhibitor of STAT1 activation and a DNA synthesis. | |||||
| Targets | DNA synthesis | |||||
| IC50 | ||||||
Fludarabine Phosphate (Fludara) Dilution Calculator
Fludarabine Phosphate (Fludara) Molarity Calculator
| Cas No. | 75607-67-9 | SDF | Download SDF |
| Synonyms | Fludura | ||
| Chemical Name | [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate | ||
| Canonical SMILES | C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(N=C2N)F | ||
| Formula | C10H13FN5O7P | M.Wt | 365.21 |
| Solubility | >17.6mg/mL in DMSO | Storage | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Fludarabine phosphate is a STAT-1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.