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Fludarabine Phosphate (Fludara)
Inhibits STAT1 activation and DNA synthesis

Fludarabine Phosphate (Fludara)

Catalog No. A8317
Size Price Stock Qty
Evaluation Sample $28.00 In stock
10mg $69.00 In stock
50mg $219.00 In stock
200mg $420.00 In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

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Chemical structure

MLN9708

Biological Activity

Description Fludarabine is an inhibitor of STAT1 activation and a DNA synthesis.
Targets DNA synthesis          
IC50            

Fludarabine Phosphate (Fludara) Dilution Calculator

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Chemical Properties

Cas No. 75607-67-9 SDF Download SDF
Synonyms Fludura
Chemical Name [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Canonical SMILES C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(N=C2N)F
Formula C10H13FN5O7P M.Wt 365.21
Solubility Soluble in DMSO > 10 mM Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Fludarabine phosphate is a STAT-1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.