|Fludarabine Phosphate (Fludara)
Inhibits STAT1 activation and DNA synthesis
Sample solution is provided at 25 µL, 10mM.
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|Description||Fludarabine is an inhibitor of STAT1 activation and a DNA synthesis.|
|Cas No.||75607-67-9||SDF||Download SDF|
|Chemical Name||[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate|
|Solubility||>17.6mg/mL in DMSO||Storage||Store at -20°C|
Fludarabine phosphate is a STAT-1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.