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Fludarabine Phosphate (Fludara)

In stock
Catalog No.
A8317
Inhibits STAT1 activation and DNA synthesis
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
Evaluation Sample
$28.00
In stock
10mg
$69.00
In stock
50mg
$219.00
In stock
200mg
$420.00
In stock

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Background

Fludarabine phosphate is a STAT-1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt365.21
Cas No.75607-67-9
FormulaC10H13FN5O7P
SynonymsFludura
Solubility≥17.6mg/mL in DMSO, <2.35 mg/mL in EtOH, ≥6.7 mg/mL in H2O with ultrasonic and warming
Chemical Name[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
SDFDownload SDF
Canonical SMILESC1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(N=C2N)F
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description Fludarabine is an inhibitor of STAT1 activation and a DNA synthesis.
Targets DNA synthesis          
IC50            

Quality Control

Chemical structure

Fludarabine Phosphate (Fludara)

Related Biological Data

Fludarabine Phosphate (Fludara)

Related Biological Data

Fludarabine Phosphate (Fludara)