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CercosporamideMnk2 and JAK3 inhibitor

Cercosporamide

Catalog No. A4511
Size Price Stock Qty
500μg $219.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Cercosporamide

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Chemical Properties

Cas No. 131436-22-1 SDF Download SDF
Chemical Name (9aS)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxodibenzofuran-4-carboxamide
Canonical SMILES CC(=O)C1=C(C=C2C(C1=O)(C3=C(C=C(C(=C3O2)C(=O)N)O)O)C)O
Formula C16H13NO7 M.Wt 331.28
Solubility Limited solubility Storage Store at -20°C
General tips N/A
Shipping Condition N/A

Background

Potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.