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Oncostatin M, human recombinant protein

Catalog No.
Oncostatin M, pleiotropic cytokine, expressed in E.Coli, active on murine cells.
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Oncostatin (OSM) is a pleiotropic cytokine produced by activated T cells, monocytes, and Kaposi’ s sarcoma cells. OSM stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, inhibits the growth of some normal and tumor cell lines, promotes cytokine release (IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells.

Human OSM cDNA encodes a 252 amino acid pre-pro-OSM polypeptide with a 25 residue signal peptide and a hydrophilic C-terminal domain that are proteolytically processed to generate the 196 residue mature OSM protein. Human OSM is active on murine cells. Recombinant human Oncostatin M is a 26 kDa protein containing 227 amino acid residues.

Biological Activity

Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells.
ED50 <2 ng/ml.          
Specific activity > 5*105 units/mg.          

Quality Control

Quality Control & DataSheet

View current batch:
    Purity: ≥98%, by SDS-PAGE and HPLC.
    Endotoxin Level:< 0.1 ng/μg/span>

Related Biological Data


Related Biological Data



Gene ID: 5008 Accession #: P13725
Alternate Names:Human Oncostatin M, h-Oncostatin M, rh-Oncostatin M, recombinant human Oncostatin M, recombinant Oncostatin M.
Source: Escherichia Coli. M.Wt: 26.0 kDa
Appearance: Lyophilized protein Storage: Store at -20°C
Formulation:Sterile filtered and lyophilized with no additives.
Solubility:Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.
Shipping Condition: Gel pack. Handling: Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.