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FPH1 (BRD-6125) Hepatocyte functional proliferation enhancer

Catalog No.B3701
Size Price Stock Qty
25mg
$199.00
In stock
10mg
$88.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Citations

1. Yuan L, Liu X, et al. "Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection." Emerg Microbes Infect. 2018 Aug 10;7(1):144. PMID:30097574

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Chemical structure

FPH1 (BRD-6125)

Related Biological Data

FPH1 (BRD-6125)

Biological Activity

Description FPH1 is a small molecule that promotes the functional proliferation of primary hepatocytes.
Targets primary human hepatocytes          
IC50            

Protocol

Cell experiment [1]:

Cell lines

Primary human hepatocytes

Preparation method

The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

20 μM; days 1 and 5

Applications

In primary human hepatocytes, FPH1 (BRD-6125) induced functional proliferation of hepatocytes and thus might be useful for expanding mature human primary hepatocytes. FPH1 induced an increase in hepatocyte nuclei count and/or elevated the number of nuclei undergoing mitosis in a concentration dependent way.

References:

[1] Shan J, Schwartz R E, Ross N T, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology, 2013.

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Chemical Properties

Cas No. 708219-39-0 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES CC1=C(C=C(C=C1)Cl)N(CC(=O)NC2=C(C=CC=C2F)F)S(=O)(=O)C
Formula C16H15ClF2N2O3S M.Wt 388.82
Solubility ≥38.9mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

FPH1 is a small molecule that promotes the functional proliferation of primary hepatocytes [1].

FPH1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. This ability of FPH1 is not dependent on the donors of the hepatocytes. It has been found that FPH1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. Besides that, FPH1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of iPS cells into iHeps. Moreover, treatment of FPH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion [1].

References:
[1] Shan J, Schwartz R E, Ross N T, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology, 2013.