VAL-083
Catalog No.
A3902
Bi-functional alkylating agent
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VAL-083 is a bi-functional alkylating agent, with potential antitumor activity.
VAL-083 can cross the blood brain barrier and appears to be selective for tumor cells. VAL-083 alkylates and crosslinks DNA which ultimately inhibit the proliferation of cancer cells. VAL-083 does not show cross-resistance to other conventional chemotherapeutic agents. The half-life of VAL-083 in the brain is long. VAL-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.
Reference:
http://www. delmarpharma.com/product_development_programs/val083/
| Storage | Store at -20°C |
| M.Wt | 146.14 |
| Cas No. | 23261-20-3 |
| Formula | C6H10O4 |
| Synonyms | Dianhydrodulcitol;Dianhydrogalactitol;VAL083;VAL 083 |
| Solubility | Soluble in DMSO |
| Chemical Name | (1S,2R)-1-[(2S)-oxiran-2-yl]-2-[(2R)-oxiran-2-yl]ethane-1,2-diol |
| SDF | Download SDF |
| Canonical SMILES | C1C(O1)C(C(C2CO2)O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | VAL-083 is a structurally unique first-in-class N7-bifunctional alkylating agent of DNA. | |||||
| Targets | DNA | |||||
| IC50 | ||||||
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
