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Tenofovir hydrate

Catalog No.
B1252
Reverse transcriptase inhibitor
Grouped product items
SizePriceStock Qty
5mg
$70.00
Ship with 10-15 days
10mg
$105.00
Ship with 10-15 days
50mg
$210.00
Ship with 10-15 days

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Email: [email protected]

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Background

Tenofovir hydrate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(HIV-1) and hepatitis B [1].

Tenofovir hydrate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. In addition, Tenofovir hydrate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of HIV-1infection with EC50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. And the EC90 values of tenofovir hydrate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1].

References:
[1] Duwal S1, Schütte C, von Kleist M.Pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against HIV-1 infection. PLoS One. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. Epub 2012 Jul 11.

Chemical Properties

StorageStore at -20°C
M.Wt305.23
Cas No.206184-49-8
FormulaC9H16N5O5P
SolubilitySoluble in DMSO
Chemical Name[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid;hydrate
SDFDownload SDF
Canonical SMILESCC(CN1C=NC2=C1N=CN=C2N)OCP(=O)(O)O.O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Tenofovir hydrate