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Sulfanilamide

Catalog No.
B2041
competitive inhibitor for bacterial enzyme dihydropteroate synthetase
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
10g
$48.00
In stock
50g
$90.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt172.2
Cas No.63-74-1
FormulaC6H8N2O2S
Solubility≥7.7mg/mL in DMSO
Chemical Name4-aminobenzenesulfonamide
SDFDownload SDF
Canonical SMILESC1=CC(=CC=C1N)S(=O)(=O)N
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Protocol

Cell experiment [1]:

Cell lines

Plasmodium falciparum

Preparation method

The solubility of this compound in DMSO is ≥7.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

380 uM

Applications

Sulfanilamide moderately inhibits the Plasmodium falciparum growth.

Animal experiment [1]:

Animal models

Male, immunosuppressed Sprague-Dawley rats

Dosage form

100, 10, and 1.0 mg/kg/day

Application

Sulfanilamide effectively inhibited P.carinii infection in immunosuppressed rat model with a concentration of 100.0 mg/kg /day. When the dose of Sulfanilamide was reduced to 10.0 mg/kg/day, P. carinii infection occurred.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Kasekarn W, Sirawaraporn R, Chahomchuen T, Cowman AF, Sirawaraporn W. Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum. Mol Biochem Parasitol. 2004 Sep;137(1):43-53. PubMed PMID: 15279950.

[2]. Hughes WT, Killmar J. Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1996 Apr;40(4):962-5. PubMed PMID: 8849260; PubMed Central PMCID: PMC163239.

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