Semaxanib (SU5416)
Catalog No.
B2304
VEGFR(Flk-1/KDR) inhibitor
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Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 238.28 |
| Cas No. | 194413-58-6 |
| Formula | C15H14N2O |
| Solubility | ≥11.9mg/mL in DMSO |
| Chemical Name | (3E)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C |
| Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
