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MT Receptor

MT (melatonin receptor) receptors are a group of G-protein coupled receptors that participate in a range of physiological and neuroendrocrine functions such as regulation of endogenous circadian rhythm, thermoregulation and prolactin expression.

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  2. A1748 Ramelteon Ramelteon, a chronohypnotic, is an orally active and highly selective melatonin receptor (MT1, MT2 and MT3) agonist that preferentially binds to MT1 and MT2 receptors leading to potent inhibition of cAMP production in human cells expressing MT1 or MT2 receptors with the half maximal inhibition concentration IC50 values of 21.2 pM/L and 53.4 pM/L respectively .

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