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PSI-6206

In stock
Catalog No.
A8189
Inhibitor of HCV RNA polymerase,potent and selective
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$176.00
In stock
Evaluation Sample
$28.00
In stock
5mg
$160.00
In stock
10mg
$264.00
In stock
25mg
$468.00
In stock
50mg
$660.00
In stock

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Email: [email protected]

Worldwide Distributors

PSI-6206 (as known as RO-2433 or GS-331007), β-D-2’-deoxy-2’-fluoro-2’-C-methyluridine, is the deaminated derivative of PSI-6130, β-D-2’-deoxy-2’-fluoro-2’-C-methylcytidine, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system.  PSI-6206, itself, does not shown any inhibitory activity towards HCV replication in the HCV subgenomic replicon system. However, the its triphosphate form, RO2433-TP, is a potent inhibitor of RNA synthesis by HCV polymerase, which inhibits both the RNA sysnthesis activity of HCV replicase (IC50 = 1.19 uM) and the RNA synthesis activity of the recombinant HCV Con1 NS58 on a heteropolymeric RNA template derived from the 3’-end of the negative strand of the HCV genome (IC50 = 0.52 uM and Ki = 0.141 uM).

Reference

Han Ma, Wen-Rong Jiang, Nicole Robledo, Vincent Leveque, Samir Ali, Teresa Lara-Jamie, Mohammad Masjedizadeh, David B. Smith, Nick Cammack, Klaus Klumpp, and Julian Symons. Characterization of the metabolic ctivation of hepatitis C virus nucleoside inhibitor β-D-2’-deoxy-2’-fluoro-2’-C-methylcytidine (PSI-6130) and identification of a novel active 5’-triphosphate species. The Journal of Biological Chemistry 2007; 282(41): 29812-29820

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt260.22
Cas No.863329-66-2
FormulaC10H13FN2O5
Solubility≥13.1mg/mL in DMSO
Chemical Name1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione
SDFDownload SDF
Canonical SMILESCC1(C(C(OC1N2C=CC(=O)NC2=O)CO)O)F
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description PSI-6206 (RO2433) is a selective inhibitor of HCV RNA polymerase .
Targets HCV          
IC50            

Quality Control

Chemical structure

PSI-6206

Related Biological Data

PSI-6206

Related Biological Data

PSI-6206

Related Biological Data

PSI-6206

Related Biological Data

PSI-6206

Related Biological Data

PSI-6206

Related Biological Data

PSI-6206

Related Biological Data

PSI-6206