In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
EC50: 50 g/mL
PicrosideII is a major an iridoid glucoside isolated from Picrorhiza scrophulariiflora Pennell (Scrophulariaceae). Previous studies have shown that picroside II can protect cardiomyocytes against oxidative stress induced by hypoxia/ reoxygenation (H/R) injury.
In vitro: Pretreated cardiomyocytes with picroside II was found to inhibit LDH activity in culture media and increase cell viability in a dose-dependent manner. Such protective effect was accompanied with significant reduction of GSH contents and the activities of SOD and GSH-Px. Attenuated MDA and GSSG contents in response to H/R injury were observed as well. In addition, picroside II treatment also inhibited calcium accumulation and ROS production in cardiomyocytes. .
In vivo: A rat focal cerebral ischemic model was established, and picroside II were given intraperitoneally. Results indicated that the damage to the structures of the neurons and the blood brain barrier (BBB) in the cortex was more severe in the model group. In the picroside II treatment group, the neurological function, the morphology and ultrastructure of the neurons, and the BBB were improved. In addition, apoptotic cell number, cerebral infarct volume, EAR and pERK1/2 expression were decreased significantly compared to the model group .
Clinical trial: N/A
 Meng FJ,Hou ZW,Li Y,Yang Y,Yu B. The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes. Pharm Biol.2012 Oct;50(10):1226-32.
 Wang T,Zhao L,Guo Y,Zhang M,Pei H. Picroside II Inhibits Neuronal Apoptosis and Improves the Morphology and Structure of Brain Tissue following Cerebral Ischemic Injury in Rats. PLoS One.2015 Apr 30;10(4):e0124099.
|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Solubility||≥22.9mg/mL in DMSO|
|Chemical Name||[1a-(hydroxymethyl)-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-6-yl] 4-hydroxy-3-methoxybenzoate|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|