Toggle Nav

Picroside II

Catalog No.
N1911
protects against oxidative stress induced by hypoxia/ reoxygenation (H/R) injury
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
20mg
$100.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

EC50: 50 g/mL

PicrosideII is a major an iridoid glucoside isolated from Picrorhiza scrophulariiflora Pennell (Scrophulariaceae). Previous studies have shown that picroside II can protect cardiomyocytes against oxidative stress induced by hypoxia/ reoxygenation (H/R) injury.

In vitro: Pretreated cardiomyocytes with picroside II was found to inhibit LDH activity in culture media and increase cell viability in a dose-dependent manner. Such protective effect was accompanied with significant reduction of GSH contents and the activities of SOD and GSH-Px. Attenuated MDA and GSSG contents in response to H/R injury were observed as well. In addition, picroside II treatment also inhibited calcium accumulation and ROS production in cardiomyocytes. [1].

In vivo: A rat focal cerebral ischemic model was established, and picroside II were given intraperitoneally. Results indicated that the damage to the structures of the neurons and the blood brain barrier (BBB) in the cortex was more severe in the model group. In the picroside II treatment group, the neurological function, the morphology and ultrastructure of the neurons, and the BBB were improved. In addition, apoptotic cell number, cerebral infarct volume, EAR and pERK1/2 expression were decreased significantly compared to the model group [2].

Clinical trial: N/A

References:
[1] Meng FJ,Hou ZW,Li Y,Yang Y,Yu B.  The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes. Pharm Biol.2012 Oct;50(10):1226-32.
[2] Wang T,Zhao L,Guo Y,Zhang M,Pei H.  Picroside II Inhibits Neuronal Apoptosis and Improves the Morphology and Structure of Brain Tissue following Cerebral Ischemic Injury in Rats. PLoS One.2015 Apr 30;10(4):e0124099.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt512.46
Cas No.39012-20-9
FormulaC23H28O13
Synonyms6-Vanilloylcatalpol
Solubility≥22.9mg/mL in DMSO
Chemical Name[1a-(hydroxymethyl)-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-6-yl] 4-hydroxy-3-methoxybenzoate
SDFDownload SDF
Canonical SMILESCOC1=C(C=CC(=C1)C(=O)OC2C3C=COC(C3C4(C2O4)CO)OC5C(C(C(C(O5)CO)O)O)O)O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Chemical structure

Picroside II