Moxidectin is a macrocyclic lactone anthelmintic drug used to control or prevent parasitic worms. Its principal use is veterinary, in animals ranging from cats and dogs to horses and cattle. Moxidectin-susceptible parasites include Strongylus vulgaris in horses and Ostertagia ostertagi in cattle. In 2018, moxidectin was approved by FDA for treating onchocerciasis (river-blindness) caused by the parasitic worm Onchocerca volvulus.
References:
1. Rolfe PF, Dawson KL, Holm-Martin M. Efficacy of moxidectin and other anthelmintics against small strongyles in horses. Australian Veterinary Journal, 1998, 76(5): 332-334.
2. Hubert J, Kerboeuf D, Cardinaud B, et al. Persistent efficacy of topical moxidectin against Dictyocaulus viviparus and Ostertagia ostertagi. Veterinary Parasitology, 1997, 68(1-2): 187-190.
3. Awadzi K, Opoku NO, Attah SK, et al. A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection. PLOS Neglected Tropical Diseases, 2014, 8(6): e2953.