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MN 64 tankyrase inhibitor

Catalog No.B5983
Size Price Stock Qty
10mM (in 1mL DMSO)
$77.00
In stock
5mg
$70.00
In stock
10mg
$110.00
In stock
50mg
$440.00
In stock
100mg
$710.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

MN 64

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Chemical Properties

Cas No. 92831-11-3 SDF Download SDF
Chemical Name 2-(4-isopropylphenyl)-4H-chromen-4-one
Canonical SMILES CC(C1=CC=C(C2=CC(C3=CC=CC=C3O2)=O)C=C1)C
Formula C18H16O2 M.Wt 264.32
Solubility ≥11.65mg/mL in DMSO Storage Store at -20°C
Physical Appearance A solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

MN-64 is a type of flavone that act as a potent and selective tankyrase inhibitor (IC50 = 6 and 72 nM for TNKS1 and TNKS2, respectively). [1]

Tankytase (TNKS) is a member of poly ADP ribose polymerases (PARPs). There are two related homologue, TNKS1 and TNKS2 that are mostly located in the nuclear pore, cytoplasm, mitotic centrosomes and the Golgi apparatus. They involve in cellular functions such as regulation of cell proliferation and promoting telomere elongation in human cells. [1]

During an assay for screening flavone TNKS inhibitors, MN-64 is discovered for abrogating STF luciferase activity at 200nM and potently inhibiting TNKS1 with IC50 of 6nM. It also selectively inhibits TNKS1 and TNKS2 without affecting any other PARPs. Moreover, MN-64 is prominently more selective than other TNKS inhibitors such as XAV939. [1]

Reference:
1.  Narwal M, Koivunen J, Haikarainen T et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9.