|Lestaurtinib JAK2/FLT3/TrkA inhibitor|
Sample solution is provided at 25 µL, 10mM.
Publications citing ApexBio Products
|Cas No.||111358-88-4||SDF||Download SDF|
|Canonical SMILES||O=C(NC1)C2=C1C(C(C=CC=C3)=C3N45)=C4C(N6[[email protected]@H]7O[[email protected]@]5(C)[[email protected]](CO)(O)C7)=C2C8=C6C=CC=C8|
|Solubility||Soluble in DMSO > 10 mM||Storage||Desiccate at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.