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Lestaurtinib

Catalog No.
A4513
JAK2/FLT3/TrkA inhibitor
Grouped product items
SizePriceStock Qty
1mg
$320.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageDesiccate at -20°C
M.Wt439.46
Cas No.111358-88-4
FormulaC25H21N3O4
SolubilitySoluble in DMSO
Chemical Name(5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one
SDFDownload SDF
Canonical SMILESO=C(NC1)C2=C1C(C(C=CC=C3)=C3N45)=C4C(N6[[email protected]@H]7O[[email protected]@]5(C)[[email protected]](CO)(O)C7)=C2C8=C6C=CC=C8
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Lestaurtinib