GW 6471
Catalog No.
B7797
PPARα antagonist
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GW 6471 (CAS 880635-03-0) is a synthetic small molecule antagonist targeting peroxisome proliferator-activated receptor alpha (PPARα). By inhibiting PPARα activity with an IC50 of approximately 0.24 μM, GW 6471 promotes increased affinity between the ligand-binding domain of PPARα and transcriptional co-repressor proteins, specifically SMRT and NCoR. Through this mechanism, GW 6471 facilitates repression of PPARα-mediated transcription. As a valuable pharmacological tool, GW 6471 is employed in biomedical research to explore PPARα signaling pathways and their implications in cellular metabolism, lipid homeostasis, and related diseases.
- 1. Xu N, Wang Q, et al. "Fenofibrate improves vascular endothelial function and contractility in diabetic mice." Redox Biol. 2018 Oct 1;20:87-97. PMID:30296701
- 2. Wang L, Xie H, et al. "rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α Signaling Pathway." Theranostics. 2017 Aug 15;7(14):3446-3460. PMID:28912887
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 619.67 |
| Cas No. | 880635-03-0 |
| Formula | C35H36F3N3O4 |
| Solubility | ≥47.6 mg/mL in DMSO; ≥18.1 mg/mL in EtOH; <2.43 mg/mL in H2O |
| Chemical Name | (S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C[C@H](N/C(C)=C\C(C4=CC=C(C(F)(F)F)C=C4)=O)CNC(CC)=O)C=C3 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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