GW 6471
Catalog No.
B7797
PPARα antagonist
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PPARα antagonist (IC50 = 0.24 μM). Enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.
- 1. Xu N, Wang Q, et al. "Fenofibrate improves vascular endothelial function and contractility in diabetic mice." Redox Biol. 2018 Oct 1;20:87-97. PMID:30296701
- 2. Wang L, Xie H, et al. "rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α Signaling Pathway." Theranostics. 2017 Aug 15;7(14):3446-3460. PMID:28912887
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 619.67 |
| Cas No. | 880635-03-0 |
| Formula | C35H36F3N3O4 |
| Solubility | Soluble in DMSO |
| Chemical Name | (S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C[[email protected]](N/C(C)=C\C(C4=CC=C(C(F)(F)F)C=C4)=O)CNC(CC)=O)C=C3 |
| Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
Related Biological Data
