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GW 6471

Catalog No.
B7797
PPARα antagonist
Grouped product items
SizePriceStock Qty
5mg
$185.00
In stock
10mg
$298.00
In stock
25mg
$588.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

GW 6471 (CAS 880635-03-0) is a synthetic small molecule antagonist targeting peroxisome proliferator-activated receptor alpha (PPARα). By inhibiting PPARα activity with an IC50 of approximately 0.24 μM, GW 6471 promotes increased affinity between the ligand-binding domain of PPARα and transcriptional co-repressor proteins, specifically SMRT and NCoR. Through this mechanism, GW 6471 facilitates repression of PPARα-mediated transcription. As a valuable pharmacological tool, GW 6471 is employed in biomedical research to explore PPARα signaling pathways and their implications in cellular metabolism, lipid homeostasis, and related diseases.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt619.67
Cas No.880635-03-0
FormulaC35H36F3N3O4
Solubility≥47.6 mg/mL in DMSO; ≥18.1 mg/mL in EtOH; <2.43 mg/mL in H2O
Chemical Name(S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide
SDFDownload SDF
Canonical SMILESCC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C[C@H](N/C(C)=C\C(C4=CC=C(C(F)(F)F)C=C4)=O)CNC(CC)=O)C=C3
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

GW 6471

Related Biological Data

GW 6471