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Gadodiamide

Gadodiamide

Catalog No.

B1765

Gadolinium-based MRI contrast agent

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Grouped product items
Size	Price	Stock	Qty
10mM (in 1mL H2O)	$50.00	In stock
50mg	$55.00	In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background
Chemical Properties
Protocol
Quality Control

Background

Gadodiamide is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels.

Chemical Properties

Storage	Store at -20°C
M.Wt	591.67
Cas No.	122795-43-1
Formula	C16H28GdN5O9
Solubility	≥29.2 mg/mL in H2O; insoluble in EtOH; ≥8.3 mg/mL in DMSO
Chemical Name	2-[bis[2-[carboxylatomethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetate;gadolinium(3+);hydrate
SDF	Download SDF
Canonical SMILES	CNC(=O)CN(CCN(CCN(CC(=O)NC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].O.[Gd+3]
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment [1]:
Animal models	Rats or monkeys
Dosage form	0.25 ~ 10 mmol/kg; i.v
Applications	In rats, a single dose of Gadodiamide at a greater than 0.5 mmol/kg induced vacuolization of the proximal tubular cells in kidneys, without affecting renal function. At a dose up to 10 mmol/kg, the vacuolization was only at the moderate degree, and was shown to regress partially during the 7 days after administration. In monkeys, administration of 0.25 mmol/kg Gadodiamide (q.d.; for 28 days) exhibited no effect on the kidneys.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Harpur ES, Worah D, Hals PA, Holtz E, Furuhama K, Nomura H. Preclinical safety assessment and pharmacokinetics of gadodiamide injection, a new magnetic resonance imaging contrast agent. Invest Radiol. 1993 Mar;28 Suppl 1:S28-43.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 98.00%

Chemical structure

Gadodiamide