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DR 2313PARP inhibitor

DR 2313

Catalog No. A4527
Size Price Stock Qty
1mg $63.00 In stock
10mg $134.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

DR 2313

Biological Activity

DR 2313 is a competitive inhibitor of PARP1 and PARP2 with IC50 of 0.20 and 0.24 μM respectively.
Targets PARPK1 PARP2        
IC50 0.20 μM 0.24 μM        

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Chemical Properties

Cas No. 284028-90-6 SDF Download SDF
Chemical Name 2-methyl-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
Canonical SMILES CC1=NC(=O)C2=C(N1)CCSC2
Formula C8H10N2OS M.Wt 182.24
Solubility Soluble to 40 mM in sterile water Storage Store at 4°C
General tips N/A
Shipping Condition N/A

Background

Competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.