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Cobimetinib (racemate)Selective MEK inhibitor

Cobimetinib (racemate)

Catalog No. A3322
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5mg $140.00 Ship Within 10-14 Days
10mg $210.00 Please Inquire
25mg $420.00 Please Inquire
50mg $630.00 Please Inquire

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Cobimetinib (racemate)

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Chemical Properties

Cas No. 934662-91-6 SDF Download SDF
Synonyms GDC-0973 racemate;XL-518;GDC 0973;XL 518;GDC0973;XL518
Chemical Name [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-(3-hydroxy-3-piperidin-2-ylazetidin-1-yl)methanone
Canonical SMILES C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Formula C21H21F3IN3O2 M.Wt 531.31
Solubility Soluble in DMSO Storage Store at -20°C
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Background

GDC-0973(XL-518; GDC 0973) is a selective inhibitor of MEK. GDC-0973 is also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.