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Cobimetinib (R-enantiomer)

In stock
Catalog No.
A3323
Selective MEK inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$1,824.00
In stock
5mg
$1,560.00
In stock

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Background

GDC-0973(XL-518) is a selective inhibitor of MEK. GDC-0973 is also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.

Chemical Properties

StorageStore at -20°C
M.Wt531.31
Cas No.934660-94-3
FormulaC21H21F3IN3O2
SynonymsGDC-0973 R-enantiomer;XL-518 R-enantiomer
SolubilitySoluble in DMSO
Chemical Name[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2R)-piperidin-2-yl]azetidin-1-yl]methanone
SDFDownload SDF
Canonical SMILESC1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Cobimetinib (R-enantiomer)