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Cobimetinib (R-enantiomer)Selective MEK inhibitor

Cobimetinib (R-enantiomer)

Catalog No. A3323
Size Price Stock Qty
5mg $205.00 Ship Within 10-14 Days
10mg $359.00 Please Inquire
25mg $617.00 Please Inquire
50mg $873.00 Please Inquire

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Cobimetinib (R-enantiomer)

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Chemical Properties

Cas No. 934660-94-3 SDF Download SDF
Synonyms GDC-0973 R-enantiomer;XL-518 R-enantiomer
Chemical Name [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2R)-piperidin-2-yl]azetidin-1-yl]methanone
Canonical SMILES C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Formula C21H21F3IN3O2 M.Wt 531.31
Solubility Soluble in DMSO Storage Store at -20°C
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Background

GDC-0973(XL-518) is a selective inhibitor of MEK. GDC-0973 is also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.