Bufalin
Catalog No.
N1507
Cardiotonic steroid
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Bufalin,is a cardiotonic steroid originally isolated from the Chinese toad venom. Experiments have shown Bufalin to have demonstrated apoptotic and cell differentiation inducing properties in U-937 (sc-2239) cells through activation of AP-1 via a mitogen
- 1. Shilong Jiang, Keyi Liu, et al. "Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha." Nat Commun 16, 7854 (2025). PMID: 40846852
- 2. Fang-jing Yu, Ying Liu, et al. "The mechanism of CPT1A involved in hepatocellular carcinoma growth and Bufalin regulates malignant behavior of hepatocellular carcinoma via CPT1A." Research Square. 21 Oct, 2024
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 386.52 |
| Cas No. | 465-21-4 |
| Formula | C24H34O4 |
| Solubility | insoluble in H2O; ≥38.7 mg/mL in DMSO; ≥8.44 mg/mL in EtOH |
| Chemical Name | 5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one |
| SDF | Download SDF |
| Canonical SMILES | C[C@@](CC[C@@H]([C@H]1CC2)[C@@](C)(CC3)[C@H]2C[C@H]3O)([C@H](CC2)C(C=C3)=COC3=O)[C@@]12O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
