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APExBIO

Bromosporine

In stock
Catalog No.
A4186
Bromodomain inhibitor,non-selective
Grouped product items
SizePriceStock Qty
5mg
$99.00
In stock
10mg
$175.00
In stock
50mg
$550.00
In stock

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Bromosporine is a broad spectrum inhibitor of bromodomains with IC50 value of 0.41 μM, 0.29μM, 0.122μM for BRD2, BRD4 and BRD9, respectively [1].

Bromodomains is a 110 amino acid protein domain which can recognize monoacetylated lysine residues and play a pivotal role in the targeting of chromatin-modifying enzymes to specific sites. It has been revealed that proteins contained BRDs involves in the development of many diseases, including cancers, inflammatory diseases and neurological diseases.

It is also reported that Bromosporine functioned on BAZ2A, BRPF3, CECR2, FALZ and TIF-1α with IC50 value of 9.36μM, 48.11μM, 0.017μM, 5.655μM and 12.38μM, respectively [1].

Reference:
[1].  University of Oxford. Structural Genomics Consortium Nuffield Dept. of Clinical Medicine. 15th Hellenic Symposium of Medicinal Chemistry Athens, 30, May, 2012.

Product Citation

Physical Appearance

A solid

Chemical Properties

StorageStore at -20°C
M.Wt404.44
Cas No.1619994-69-2
FormulaC17H20N6O4S
Solubility≥40.4 mg/mL in DMSO, <2.43 mg/mL in EtOH, <2.51 mg/mL in H2O
Chemical Nameethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate
SDFDownload SDF
Canonical SMILESCC1=C(NS(C)(=O)=O)C=C(C2=NN3C(C(NC(OCC)=O)=C2)=NN=C3C)C=C1
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description Bromosporine is a non-selective inhibitor of bromodomain.
Targets bromodomain          
IC50            

Quality Control

Quality Control & MSDS

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Chemical structure

Bromosporine

Related Biological Data

Bromosporine

Related Biological Data

Bromosporine